MPH5041 Introductory Biostatistics - Formulation and Evaluation of Research Objectives - Assignment Help

Modules 4-7 Formative Assessments feedback will guide you appropriately to solve all

• Alignment with Learning Outcomes (LO): Please see the Assessment 2 E-book
• General Instructions: Please see the Assessment 2 E-book
• Instructions for Submission: Please see the Assessment 2 E-book
• Marking Criteria: Please see the Assessment 2 E-book
• Required Data: Please find the data files “CVD-Data” and “DBP-Data” in the “Assessment 2” section on the moodle Required access to IBM SPSS to open these data files.
• Returning date: Please see the Assessment 2 E-book
• Please don’t post any discussions related to the AT2 questions/answers on Discussion Violation of this request may affect your grade in AT2.
• In case, you need any clarification on any questions please feel free to post your query on “Forum, Ask Your Instructor” with a proper subject.

Data Description (CVD-Data): Consider a study where twelve baseline variables (e.g., age, gender, weight, BMI, etc.) among others were collected from each of the 1429 participants. Out of the 1429 participants, 952 had a history of being treated with Drug-X on a regular basis. The objective of the study was to investigate whether Drug-X was protective for various risk factors of cerebrovascular vascular disease (CVD). The participants were then followed for 5 years and their mortality status was recorded. The short and long names of the variables are given in Table 1. Note: Baseline Variable is collected at the beginning of a study.

Table 1: Variable description for the study

Question 1 [5 marks]: Consider that an investigator aims to assess whether ‘Drug-X’ was protective for ‘mortality’ in the study sample. Evaluate the investigator’s aim by presenting the related data on an appropriate graph (Hint: no additional summary statistics or significance test required for answering this question).

Question 2 [35 marks]: Using appropriate statistical method(s) investigate whether patients who had a history of being treated with Drug-X on a regular basis have significantly different systolic blood pressure (SBP), diastolic blood pressure (DBP) and cholesterol level (CHL) compared to patients without Drug-X treated.

Please fill up the following table from the above analysis results.

Question 3 [20 marks]: Using appropriate statistical methods evaluate the significance of difference of CHL and SBP between the BMI categories.

Question 4 [20 marks]: Using appropriate statistical methods compare patients’ SBP and DBP by STROKE status.  Hint: Statistical significance test required.

Question 5 [15 marks]: In a clinical trial, 35 subjects were treated with a new drug to show the efficacy of the drug in reducing diastolic blood pressure (DBP). Their blood pressure was observed before the treatment and after 10 weeks of the treatment (see the DBP-data on the Moodle site). Using appropriate statistical method(s) evaluate whether the drug is significantly effective.

Question 6 [5 marks]: State the learning outcomes of Modules 4-7 and describe how this assessment is aligned with these learning outcomes (maximum of 150 words, this will be excluded from the total word count of this assessment).